P-33: Comparison of impedance cardiography and pulse wave contour analysis measurement of arterial compliance in healthy and diseased subjects

Lose of arterial compliance is indicative of vascular remodeling and endothelial dysfunction. These changes represent a significant risk factor for the development of hypertension and cardiovascular end organ diseases. The purpose of this study was to compare two noninvasive methods of arterial compliance measurement, impedance cardiography (ICG) and pulse wave contour analysis (PWC). A total of 17 healthy volunteer subjects and 88 diseased subjects with either hypertension or peripheral vascular disease were evaluated. Large (C1) and small (C2) artery elasticity derived from PWC (CR-2000 CV Profiler, HDI, Eagan, MN) were compared to total arterial compliance (TAC) and TAC index (TACI) from ICG (BioZ ICG Monitor, CardioDynamics, San Diego, CA). TAC was calculated as stroke volume/pulse pressure and TACI as stroke index/pulse pressure. Healthy subjects were mean 23 ± 1 years of age, 65% male, 65% white, with a systolic/diastolic blood pressure of 119 ± 8/72 ± 7 mm Hg. Disease subjects were 55 ± 14 years of age, 47% male, 80% white, with a systolic/diastolic blood pressure of 153 ± 26/90 ± 13 mm Hg. Compared to healthy subjects, disease subjects had lower C1 (10.8 ± 4.9 vs. 18.9 ± 5.7 mL/mm Hg x 10, p