P-564: Impaired fasting glucose in hypertensive patients

Purpose: To determine the prevalence of multiple risk factors for CAD, especially previously undetected IFG and diabetes mellitus, in a sample of treated hypertensive patients. Methods: We conducted this cross-sectional study on 108 patients, 50 years and older, with essential hypertension within an urban academic outpatient primary care practice. We obtained blood pressure measurements and laboratory data, including fasting glucose and lipid values from all subjects. We reviewed the outpatient medical record to determine CAD risk factors and current antihypertensive medications. We totaled the number of CAD risk factors to derive a CAD risk score. The mean result of RIA on two timed overnight urine specimens was used to determine the presence of microalbuminuria in patients. To analyze the data, we stratified the entire sample according to the presence or absence of impaired fasting glucose, then used two-tailed unpaired t-tests to compare parameters between the two groups. Pearson's correlation coefficient was calculated to examine the relationship between FBG, UAE, BMI, lipid values, and the CAD risk score. The analysis was adjusted for patient usage of antiproteinuric medications. Results: We detected previously undiagnosed impaired fasting glucose in 13.9% of subjects. HDL score was significantly lower in subjects with IFG. The FBG value directly and strongly correlated with the degree of CAD risk. Conclusions: Impaired fasting glucose (prediabetes) and diabetes mellitus occur with increased frequency in hypertensive patients. IFG and diabetes in hypertension are associated with greater cardiovascular risk.