P-535: Relationship between left ventricular mass and 24 hour blood pressure profiles in black-African patients with severe hypertension

The relationship between left ventricular mass (LVM) and ambulatory blood pressure (ABP) profiles has not been investigated in black African patients with severe hypertension. Fifty nine patients Black patients with ambulatory day diastolic blood pressures (DBP) ≥110 and ≤140mm Hg with echocardiographic determined LVM, received either nisoldipine (n=30; 40 mg once daily) or enalapril (n=29; 40mg/D) for 2 months in a double blind randomised trial. The patients (33 female) aged (46±9 years; BSA (1.8±0.2 kg/m2)) had baseline mean 24h ambulatory BP 180±13/118±6 mm Hg. Patients receiving nisoldipine (NP) decreased mean 24h ABP (180±12/119±7 mm Hg to 143±15/94±9 mm Hg) and LVM index (LVMI 146±41 to 124±34g/m2) significantly. In contrast, those receiving enalapril a modest decrease in mean 24h ABP (179±14/117±5 mm Hg to 169±19/110±12 mm Hg; p