P-245: Pulse pressure as a predictor of mortality in elderly survivors of acute myocardial infarction treated with calcium channel blockers

We reviewed data from the Cooperative Cardiovascular Project (CCP). This project is a database of one of the largest number of elderly patients with an acute myocardial infarction (AMI). Pulse pressure data was analyzed by quartile to determine the impact of Calcium channel blockers (CCBs) on survival of elderly patients. Data was not analyzed as to specific types of CCBs. (See Table) Pulse pressure receivng CCB not receivng CCB difference in risk relative risk 95% confidence interval white male 18,061 ≤46mmHG 4644 14640 0.1 1.003 1.000-1.005 46.1-55mmHG 4135 9890 3.0 1.161 1.158-1.163 55.1-66mmHG 4706 9361 2.2 1.34 1.132-1.137 66.1-157mmHG 4576 7187 3.0 1.157 1.155-1.159 white female 17,664 ≤46mmHG 3218 8766 1.1 1.048 1.046-1.051 46.1-55mmHG 3518 7550 1.8 1.086 1.083-1.088 55.1-66mmHG 4695 8406 1.2 1.055 1.179-1.182 66.1-157mmHG 6233 8762 4.4 1.181 1.179-1.182 black male 3,842 ≤46mmHG 248 736 -0.9 0.968 0.939-0.996 46.1-55mmHG 252 448 1.7 1.066 1.036-1.095 55.1-66mmHG 260 455 -2.6 0.902 0.870-0.934 66.1-157mmHG 287 396 -2.6 0.915 0.888-0.942 black female 2,392 ≤46mmHG 285 655 -1.1 0.961 0.937-0.986 46.1-55mmHG 284 520 -9.3 0.721 0.693-0.749 55.1-66mmHG 408 607 -1.8 0.934 0.913-0.954 66.1-157mmHG 593 670 -4.9 0.857 0.843-0.870 The data showed that at matching Pulse pressure quartile elderly African-American men and elderly African-American women had a lower relative risk of death than their white counterparts while receiving CCBs in the two year period following AMI. This data suggests a trend in survival benefit of elderly African-Americans treated with CCBs post-AMI.