P-439: Comparative effects of amlodipine, ramipril and telmisartan on 24-hour ambulatory blood pressure in mild to moderate hypertensive patients

The objective of the present study was to compare the antihypertensive effects of amlodipine (AML), ramipril (RAM) and telmisartan (TEL) on 24-hour ambulatory blood pressure (BP) in patients with mild to moderate essential hypertension. For this purpose, 57 patients (41 M/16F) with a mean age of 60.1±7.0 years were enrolled in the study and were randomised to either RAM 2.5 mg (n=17), AML 5 mg (n=22) or TEL 80 mg (n=18) for a period of 8 weeks. Patients were respectively titrated to RAM 5 mg and 10 mg after 1 and 4 weeks of treatment and to AML 10 mg at week 4. Patients treated with TEL received 80 mg during the 8 weeks of the study. Ambulatory BP monitoring was performed at baseline and at the end of the 8-week treatment period. At the end of the study, TEL and AML provided significant (p