P-217: Efficacy of enalapril in secondary arterial hypertension

We studied possibility of left ventricular hypertrophy (LVH) regression to suppress the plasma renin activity (PRA) under the influence of ACE inhibitors. Fifty-four patients (pts) with mild to moderate secondary hypertension of renal genesis (chronic pyelonephritis) were examined by 2-D guided M-mode Echocardiography, Doppler-Echocardiography. PRA estimated as nonactive renin (NR) was measured by radioimunoassay (than lower NR the higher activity of plasma renin). LV mass index (LVMI), early filling velocity (E), late filling velocity (A), E/A ratio, isovolumic relaxation time (IVRT) and deceleration time (DT) were detected. En was administered in dose of 10 –20 mg o. d. Examination was performed at baseline, 4 weeks and 12 months after therapy. Thirty-eight normotensives served as controls. At baseline NR was significantly low (2.7±0.8 vs 4.8 ± 0.8 ng/ml/hr, p