P-535: Vasodilatation function in elder hypertensives with and without diabetes mellitus

To explore the vasodilatation function changes in elder hypertnsives with (HT+DM) and without (HT) diabetes mellitus. 61 elder patients was entered into 3 groups: Hypertensives (HT, n=23), Hypertensives with diabetes (HT+DM, n=23), and normotensives without diabetes(NT, n=15). Endothelium dependent vasodilatation and non-endothelium dependent vasodilatation function was determined using high resolution B mode sonography technique. Plasma endothelin level was determined using enzyme labeled immunoassay. It was found that endothelium dependent vasodilatation was significantly different among HT+DM, HT and NT patients ( HT+DM: 4.54 %±2.51 %, HT:7.51 % ±3.20 %, vs NT:15.67 %±5.76%, P < 0.01 respectively). Marked deterioration of vasodilatation function was found in HT+DM than in HT patients P = 0.029). There was no significant difference of non- endothelium dependent vasodilatation function among HT+DM, HT and NT patients (P > 0.05). Linear regression analysis shown that there was a close correlation between endothelium dependent vasodilatation function and plasma glucose, ET-1 and SBP (P < 0.01 respectively. Multiple stepwise regression analysis showed that systolic blood pressure was an only independent factor for brachial vasodilatation function (R2 = 0.397, df = 60, P < 0.01), and ET-1 was an only independent factor for fasting plasma glucose (R2 = 0.145, df = 60, P = 0.02). It is thus concluded that hypertension per se is an independent risk factor for vascular endothelial function damage in elder hypertensives. Diabetes mellitus aggravated the deterioration of vascular endothelial function in hypertensives.