P-84: Plasma thrombogenesis and platelet activity under administration of aspirin and thienopyridine in noninvasively managed acute coronary syndrome patients

Study goal was to compare platelet (PLT) and plasma coagulation reactions in acute coronary syndrome (ACS) patients (pts) (under conservative management), treated with aspirin (ASA) and with combination of ASA plus ticlopidine (TCL). Study population consisted of 35 pts prior ASA users, admitted to CCU with high risk ACS without ST elevation. 15 pts were randomized to ASA (325 mg/d) - 1st group, 20 pts - to TCL (500 mg/d) + ASA (325 mg/d) - 2nd group. No anticoagulants were used in this study. Spontaneous and inducted by ADP, serotonin, thrombin PLT aggregation (Agr), PLT factors 3, 4, 5, 9, antithrombin III, fibrinogen (F), factor XIII, fibrin-monomers (FM), D-dimers, euglobulin lysis, intensity of endogenous fibrinolysis (IEF) and of PLT-dependent fibrinolysis (PF) by graphic turbodimetric assay were investigated before ASA and TCL intake and thereafter on 14 day of treatment. Baseline values of all parameters didn’t differ significantly (SN) between the groups. On 14th days of treatment in the 2nd group vs baselinewas found changes of almost all PLT functions (SN differences vs 1st group) with the most profound depression in Agr: spontaneous Agr decreased in 7,2 times, ADP-Agr - in 7,7 times, serotonin-Agr - in 3,8 times (all values p