P-179: Extracardiac mechanisms of left ventricular remodeling in essential hypertensive patients

The purpose of this study is to investigate the influence of the systemic hemodynamics, plasma renin activity (PRA) and serum concentrations of aldosterone (CA) in the development of left ventricular (LV) geometry in patients with EH. 122 patients with I - III (JNC-VI) (71 men and 51 women, mean age 49.6 ±1.6 years) were examined by 2-D guided M-mode Echocardiography and Radiocardiography with 131I -albumin. PRA and CA were measured by radioimunoassay. Forty-eight normotensive healthy subjects served as controls. Correlation analysis was performed to detect the influence of the hemodynamic and hormonal factors in development of the distinct patterns of LV geometry. Correlation analyses revealed that BP promotes to the development of the LV concentric remodeling. Systolic BP was correlated with posterior wall thickness (PWT) and septal wall thickness (SWT) (r=0.5,P< 0.05; r=0.6, P