P-117: Suprasystolic arterial pulse waveform analysis: new hemodynamic parameter for hypertension

PW Arterial Pulse Waveform () Analysis, a recent technological advance, has allowed assessing hemodynamic function no previously recognized in hypertension. In this work, we present new observations on the Suprasystolic Arterial PW. Methods: 31 pts (17 female, 14 males, 55.3±9 yrs., BP 161±31/ 88.5±12 mm Hg) out of 91 hypertensives with non-invasive hemodynamic (DynaPulse 200M), ECG/Phono and Echocardiography studies were randomly selected along with 15 Normotensive NT subjects (8 female, 7 males, 45±7 yrs., 119±14/ 73±6 mm Hg. All had hemodynamic studies basal and 5 minutes after handgrip test: 4 parameters were relevant on Suprasystolic PW: a) Aortic Augmentation index (AIA, as described by others), b) T- Aortic Reflectance Wave (ARW), Pulse Wave Velocity ( PWV aorta-brachial, estimated), d) Suprasystolic PW changes during hand-grip and flow mediate vasodilatation. Results: a) AIA in 32% of HT (20.8±5 vs 0% in NT); Time-ARW: 228 ± 7 msc vs 350 ±4 msc in NT with similar LVET (450±54 msc vs 442±54 in NT (p< 0.001); during hand-grip T-ARW was 200 ± 3msc in HT vs 320 ± 8 msc in NT: PWV (aortic-brachial estimation) range from 8.4-19.2 m/s in HT vs 3.75-8.4 m/s in NT (p