P-153: Noninvasive measurement of central venous pressure

Hemonix, Inc. has developed a noninvasive hemodynamic monitor to measure the blood pressure profile, blood volume distribution profile, and vessel wall compliance profile of the seven compartments in a vascular bed of the limb of a patient. The HemoView PeriVasc monitor can determine the blood pressure, blood volume, and vessel compliance characteristics of the large arteries, small arteries, arterioles, capillaries, venules, small veins, and large veins including Central Venous Pressure (“CVP”). The PeriVasc sensor is based upon a standard blood pressure cuff with an integrated proprietary bioimpedance sensor. Therefore, it is easy to use in most clinical settings. An unblinded clinical trial was conducted at the Portland Oregon Veterans Administration Hospital under the direction of William E. Holden, M.D. in order to demonstrate the clinical efficacy of the PeriVasc monitor for noninvasive measurement of the central venous pressure. The study was limited to critically ill adult patients with an indwelling central venous catheter. Nine patients were enrolled in the study and 28 measurements performed on these nine patients. Of the 28 measurements, 5/28 were ideal, 16/28 were within +/- 1 mmHg of ideal, and 26/28 were within +/- 2 mmHg of ideal. CVP values ranged from 5 to 17 mmHg. The results of this study indicate that the HemoView PeriVasc monitor may offer a safe and cost-effective alternative to the placement of central venous catheters for the measurement of CVP. NI-CVP will be useful in the routine diagnosis of compensated heart failure and the management of pulmonary hypertension patients. In critical care applications where NI-CVP can substitute for a central line, the institution can realize substantial cost savings and improve quality of care. Additional applications for the HemoView PeriVasc include comprehensive hypertension diagnosis that allows precise determination of the causative mode of the hypertension. Differentiating between hypervolemia, peripheral resistance, and/or vessel compliance as the source of the hypertension need no longer be in question. The comprehensive pressure, volume and compliance profiles of the HemoView PeriVasc will assist physicians in diagnosing hypertension and prescribing a treatment protocol targeted to the source of the hypertension in each patient. Research applications include hypertension etiology, pressure and fluid control systems, pharmaceutical affects, and investigations of microvascular behaviors i