P-78: Cardiovascular reactivity and diurnal arterial compliance during nebivolol treatment of young obese essential hypertensives

To evaluate changes in systemic and peripheral hemodynamics in resting, under stress tests and daily life conditions during short-term treatment with nebivolol in a special high-risk population twelve randomly selected verified never treated essential hypertensives (aged 38.6±8.4 years, body mass index 31.2±5.2 kg/m2) underwent ambulatory blood pressure monitoring (DynaPulse 5000A; Pulse Metric, Inc., USA), standard mental arithmetic (MT) and cold pressor (CT) tests before and 4 weeks after treatment with nebivolol (5 mg once daily). Systemic and local (brachial artery) vascular hemodynamics parameters were derived blindly from each measurement by previously validated web-based pulse dynamics analysis technology. Ambulatory BP and HR were significantly reduced by nebivolol without excessive nighttime falls and variability affecting. 24-hour, but not resting systemic vascular compliance was significantly improved (1.19±0.11 vs. 1.36±0.16 mL/mm Hg; p