P-75: Antihypertensive treatment, oxidative stress and activity of antioxidant enzymes

Objective: To evaluate the impact of the antihypertensive treatment, based in beta-blockers or ARA II, in the oxidative status, the extent of DNA oxidation and the antioxidant enzymatic activities in essential hypertensive patients. Design and Methods: Thirty-five essential hypertensive subjects (mean age 48 yr, 24 males, SBP 160±18 mmHg, DBP 97±12 mmHg) were included. In whole blood and lymphocytes, oxidative stress status (GSSG/GSH), DNA-damage (8-oxo-2′-deoxyguanosine in lymphocytes) and the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (Gpx), were measured at baseline and after three months of antihypertensive treatment. BP changes from baseline was assessed by 24h ambulatory BP. Subjects were treated with beta-blockers (n=19) or ARA II (n=16), adding HCZT when necessary to achieve 24h MBP