P-312: Effects of candesartan on left ventricular geometry and diastolic function in hypertensive patients with left ventricular hypertrophy. The VIPE study

The VIPE study was designed to assess the efficacy of candesartan on hypertensive echocardiographic left ventricular hypertrophy (LVH) at short term. In this work we report the effects of the drug on the ventricular geometric pattern and the diastolic function. 97 hypertensive patients (70% females (F) and 30% males (M), age 68.9±9.5 years, BMI 29.3±4.7 kg/m2) with LVH diagnosed by echo were included. LVH criteria were left ventricular mass index (LVMI) ≥134 g/m2 or ≥110 (M or F). The patients were treated with a candesartan-based regimen (8mg, 16mg, +HCTZ 12.5mg, +add-on drugs to target BP