P-463: The impact of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP) and C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease
Background: Inflammation plays a major role in the development of acute coronary syndromes. However, the role of viral infections remains unclear. We examined the role of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP), C-reactive protein (CRP),...
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| Veröffentlicht in: | American journal of hypertension 2005-05, Vol.18 (S4), p.174A-174A |
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| creator | Nikolopoulou, Aggeliki Tousoulis, Dimitris Antoniades, Charalambos Petrochilou, Katerina Kontou, Chrysoula Konniari, Katerina Drolias, Apostolos Tentolouris, Costas Pitsavos, Christos Stefanadis, Christodoulos |
| description | Background: Inflammation plays a major role in the development of acute coronary syndromes. However, the role of viral infections remains unclear. We examined the role of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP), C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease. Methods: The study population consisted of 97 patients: 27 patients with stable angina, 40 patients with unstable angina and 25 controls with angiographically normal coronaries. Forearm blood flow was measured using venous occlusion strain-gauge plethysmography. Endothelium dependent (EDD) and endothelium independent (EID) dilation were expressed as the % change of flow from baseline to the maximum flow during reactive hyperemia or after sublingual nitroglycerin administration respectively. IgG and IgM antibodies against HAV, CMV, HSV and HP as well as C-reactive protein levels (CRP) were determined by admission. Results: EDD was higher in healthy subjects (78.0±9.8%) compared to patients with unstable angina (57.3±4.5%, p |
| doi_str_mv | 10.1016/j.amjhyper.2005.03.480 |
| format | Article |
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However, the role of viral infections remains unclear. We examined the role of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP), C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease. Methods: The study population consisted of 97 patients: 27 patients with stable angina, 40 patients with unstable angina and 25 controls with angiographically normal coronaries. Forearm blood flow was measured using venous occlusion strain-gauge plethysmography. Endothelium dependent (EDD) and endothelium independent (EID) dilation were expressed as the % change of flow from baseline to the maximum flow during reactive hyperemia or after sublingual nitroglycerin administration respectively. IgG and IgM antibodies against HAV, CMV, HSV and HP as well as C-reactive protein levels (CRP) were determined by admission. Results: EDD was higher in healthy subjects (78.0±9.8%) compared to patients with unstable angina (57.3±4.5%, p<0.05) or stable angina (69.3±5.4%, p<0.05), while patients with stable angina appeared to have higher EDD than patients with unstable angina (p<0.05). CRP levels were significantly lower in patients with stable angina (6.3±1.05mg/dl) compared to patients with unstable angina (19.9±3.1 mg/dl, p<0.05). Healthy controls had significantly lower CRP compared to all the other groups (1.05±0.3 mg/dl, p<0.01 vs all). The frequency of IgG-HAV was significantly lower in controls (9/12 or 75%) compared to patients with stable (26/27 or 96.6%, p<0.05) or unstable angina (40/40 or 100%, p<0.05). EID, IgG and IgM for CMV, HSV and HP did not differ between groups. Conclusions: Patients with stable angina had higher EDD and lower levels of CRP and anti-HAV IgG, compared to unstable syndromes. This finding suggests that enhanced inflammatory process with the involvment of viral infection of hepatitis A may participate in endothelial dysfunction and clinical instability in patients with coronary artery disease.]]></description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/j.amjhyper.2005.03.480</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Coronary Artery Disease ; Infections</subject><ispartof>American journal of hypertension, 2005-05, Vol.18 (S4), p.174A-174A</ispartof><rights>Copyright Nature Publishing Group May 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Nikolopoulou, Aggeliki</creatorcontrib><creatorcontrib>Tousoulis, Dimitris</creatorcontrib><creatorcontrib>Antoniades, Charalambos</creatorcontrib><creatorcontrib>Petrochilou, Katerina</creatorcontrib><creatorcontrib>Kontou, Chrysoula</creatorcontrib><creatorcontrib>Konniari, Katerina</creatorcontrib><creatorcontrib>Drolias, Apostolos</creatorcontrib><creatorcontrib>Tentolouris, Costas</creatorcontrib><creatorcontrib>Pitsavos, Christos</creatorcontrib><creatorcontrib>Stefanadis, Christodoulos</creatorcontrib><title>P-463: The impact of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP) and C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description><![CDATA[Background: Inflammation plays a major role in the development of acute coronary syndromes. However, the role of viral infections remains unclear. We examined the role of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP), C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease. Methods: The study population consisted of 97 patients: 27 patients with stable angina, 40 patients with unstable angina and 25 controls with angiographically normal coronaries. Forearm blood flow was measured using venous occlusion strain-gauge plethysmography. Endothelium dependent (EDD) and endothelium independent (EID) dilation were expressed as the % change of flow from baseline to the maximum flow during reactive hyperemia or after sublingual nitroglycerin administration respectively. IgG and IgM antibodies against HAV, CMV, HSV and HP as well as C-reactive protein levels (CRP) were determined by admission. Results: EDD was higher in healthy subjects (78.0±9.8%) compared to patients with unstable angina (57.3±4.5%, p<0.05) or stable angina (69.3±5.4%, p<0.05), while patients with stable angina appeared to have higher EDD than patients with unstable angina (p<0.05). CRP levels were significantly lower in patients with stable angina (6.3±1.05mg/dl) compared to patients with unstable angina (19.9±3.1 mg/dl, p<0.05). Healthy controls had significantly lower CRP compared to all the other groups (1.05±0.3 mg/dl, p<0.01 vs all). The frequency of IgG-HAV was significantly lower in controls (9/12 or 75%) compared to patients with stable (26/27 or 96.6%, p<0.05) or unstable angina (40/40 or 100%, p<0.05). EID, IgG and IgM for CMV, HSV and HP did not differ between groups. Conclusions: Patients with stable angina had higher EDD and lower levels of CRP and anti-HAV IgG, compared to unstable syndromes. This finding suggests that enhanced inflammatory process with the involvment of viral infection of hepatitis A may participate in endothelial dysfunction and clinical instability in patients with coronary artery disease.]]></description><subject>Coronary Artery Disease</subject><subject>Infections</subject><issn>0895-7061</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNotkN-r0zAUx4MoOK_-C3LAFy_YmqRJ2vk2ht4JE4cbIr6UND2zmV1Tk-x6-1_7J5iy-xT4fH-cc0LIa0ZzRpl6f8r1-dRNI_qcUypzWuSiok_Igi0Fy0rO5VOyoNVSZiVV7Dl5EcKJUiqUYgvyb5cJVXyAQ4dgz6M2EdwROhx1tNEGWMG99e4S4O1m9f32HZgpujP-0r1LfMbrLzPu0I8YIKSKHh_gUdvsr1pvjWtSNXoYp955m6TdLeihhXXmMSn2HmH0LqIdUuW3XYq5AXBoXZzjuofjZUi2BOeU6e1gTaIh6sb2Nk6QgvPOOMQAf23swDjvBu0n0D4NnqC1AXXAl-TZUfcBXz2-N-Tw6eNhvcm2X-8-r1fbzColM-SK69ZoJrgujSnLSiiqjZZmKUspDJVIK9YoUXHRKEmXTcFbWfCKCuTp24sb8uZam676c8EQ65O7-CFNrBnlSkomlEyu7OqyIeJDPXp7ThvX2v-uVVmUst78-FkXnO63d3tWs-I_vKCYvA</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Nikolopoulou, Aggeliki</creator><creator>Tousoulis, Dimitris</creator><creator>Antoniades, Charalambos</creator><creator>Petrochilou, Katerina</creator><creator>Kontou, Chrysoula</creator><creator>Konniari, Katerina</creator><creator>Drolias, Apostolos</creator><creator>Tentolouris, Costas</creator><creator>Pitsavos, Christos</creator><creator>Stefanadis, Christodoulos</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>200505</creationdate><title>P-463: The impact of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP) and C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease</title><author>Nikolopoulou, Aggeliki ; Tousoulis, Dimitris ; Antoniades, Charalambos ; Petrochilou, Katerina ; Kontou, Chrysoula ; Konniari, Katerina ; Drolias, Apostolos ; Tentolouris, Costas ; Pitsavos, Christos ; Stefanadis, Christodoulos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i665-e262adca142a7cc778460aca5c95754c05e081b64824b6509b32d532804e29413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Coronary Artery Disease</topic><topic>Infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikolopoulou, Aggeliki</creatorcontrib><creatorcontrib>Tousoulis, Dimitris</creatorcontrib><creatorcontrib>Antoniades, Charalambos</creatorcontrib><creatorcontrib>Petrochilou, Katerina</creatorcontrib><creatorcontrib>Kontou, Chrysoula</creatorcontrib><creatorcontrib>Konniari, Katerina</creatorcontrib><creatorcontrib>Drolias, Apostolos</creatorcontrib><creatorcontrib>Tentolouris, Costas</creatorcontrib><creatorcontrib>Pitsavos, Christos</creatorcontrib><creatorcontrib>Stefanadis, Christodoulos</creatorcontrib><collection>Istex</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikolopoulou, Aggeliki</au><au>Tousoulis, Dimitris</au><au>Antoniades, Charalambos</au><au>Petrochilou, Katerina</au><au>Kontou, Chrysoula</au><au>Konniari, Katerina</au><au>Drolias, Apostolos</au><au>Tentolouris, Costas</au><au>Pitsavos, Christos</au><au>Stefanadis, Christodoulos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P-463: The impact of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP) and C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2005-05</date><risdate>2005</risdate><volume>18</volume><issue>S4</issue><spage>174A</spage><epage>174A</epage><pages>174A-174A</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract><![CDATA[Background: Inflammation plays a major role in the development of acute coronary syndromes. However, the role of viral infections remains unclear. We examined the role of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP), C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease. Methods: The study population consisted of 97 patients: 27 patients with stable angina, 40 patients with unstable angina and 25 controls with angiographically normal coronaries. Forearm blood flow was measured using venous occlusion strain-gauge plethysmography. Endothelium dependent (EDD) and endothelium independent (EID) dilation were expressed as the % change of flow from baseline to the maximum flow during reactive hyperemia or after sublingual nitroglycerin administration respectively. IgG and IgM antibodies against HAV, CMV, HSV and HP as well as C-reactive protein levels (CRP) were determined by admission. Results: EDD was higher in healthy subjects (78.0±9.8%) compared to patients with unstable angina (57.3±4.5%, p<0.05) or stable angina (69.3±5.4%, p<0.05), while patients with stable angina appeared to have higher EDD than patients with unstable angina (p<0.05). CRP levels were significantly lower in patients with stable angina (6.3±1.05mg/dl) compared to patients with unstable angina (19.9±3.1 mg/dl, p<0.05). Healthy controls had significantly lower CRP compared to all the other groups (1.05±0.3 mg/dl, p<0.01 vs all). The frequency of IgG-HAV was significantly lower in controls (9/12 or 75%) compared to patients with stable (26/27 or 96.6%, p<0.05) or unstable angina (40/40 or 100%, p<0.05). EID, IgG and IgM for CMV, HSV and HP did not differ between groups. Conclusions: Patients with stable angina had higher EDD and lower levels of CRP and anti-HAV IgG, compared to unstable syndromes. This finding suggests that enhanced inflammatory process with the involvment of viral infection of hepatitis A may participate in endothelial dysfunction and clinical instability in patients with coronary artery disease.]]></abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1016/j.amjhyper.2005.03.480</doi></addata></record> |
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| subjects | Coronary Artery Disease Infections |
| title | P-463: The impact of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP) and C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease |
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