P-463: The impact of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP) and C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease

Background: Inflammation plays a major role in the development of acute coronary syndromes. However, the role of viral infections remains unclear. We examined the role of hepatitis A virous (HAV), cytomegalovirus (CMV), herpes simplex virus (HSV), helicobacter pylori (HP), C-reactive protein (CRP), on endothelial function and clinical stability in patients with coronary artery disease. Methods: The study population consisted of 97 patients: 27 patients with stable angina, 40 patients with unstable angina and 25 controls with angiographically normal coronaries. Forearm blood flow was measured using venous occlusion strain-gauge plethysmography. Endothelium dependent (EDD) and endothelium independent (EID) dilation were expressed as the % change of flow from baseline to the maximum flow during reactive hyperemia or after sublingual nitroglycerin administration respectively. IgG and IgM antibodies against HAV, CMV, HSV and HP as well as C-reactive protein levels (CRP) were determined by admission. Results: EDD was higher in healthy subjects (78.0±9.8%) compared to patients with unstable angina (57.3±4.5%, p