P-223: Assessment of the efficacy, safety and tolerability of a fixed dose combination of Perindopril/Indapamide (2mg/0.625 mg) in adult patients with mild to moderate hypertension

Objective: To assess the efficacy, safety and tolerability of a fixed dose combination of Perindopril 2 mg and Indapamide 0.625 mg in adult Indian patients with mild to moderate hypertension. Methods: A prospective, multicentric, rater-blind, non-comparative study was conducted in a total of 130 patients of either sex, between 18- 75 years of age with blood pressure (BP) levels of systolic BP (SBP) of 140–200 mmHg and diastolic BP (DBP) of 95–114 mmHg. After a placebo run-in period of 2 weeks, each patient received a fixed dose combination of Perindopril/ Indapamide (2mg/ 0.625mg) once daily, for 8 weeks. BP was assessed at the end of every 2 weeks. Tolerability and safety was assessed by physical examination, laboratory parameters and evaluation of adverse events. Results: A total 123 patients completed the trial. There was a significant fall (p