P-540: Metabolic syndrome increases the risk of hypertension-induced organ damage in hypertensives attending primary care centers. ERIC-HTN study

The objective was to assess the influence of metabolic syndrome on hypertension-related organ damage (left ventricular hypertrophy and renal function) in a large survey of hypertensives who attend primary care clinics. Subjects and Methods: Hypertensive subjects of both genders, aged >55 years were randomly selected among those attending primary care centers all over Spain. In all subjects, the existence of cardiovascular disease and cardiovascular risk factor status (body mass index, baseline glucose, lipid profile, and diabetes) were assessed. The EKG-left ventricular hypertrophy was assessed by using the Cornell criteria, and glomerular filtration rates were calculated using the Cockroft-Gault formula. Metabolic Syndrome was defined according the NECP, in which BMI >28,8 kg/m2 for males and >26,2 kg/m2 for females instead of waist circumference was considered as a criteria. Risk for LV hypertrophy and/or renal insufficiency were sougth by using a logistic regression analysis in which age, sex, and body mass index were included. Results: A total of 12857 subjects (mean age 67,6 years, 55,4% women) were included. After adjusting for age, sex and BMI, the relative risk for LV hypertrophy was significantly higher in diabetics 2,0 [1,8–2,2] and in non-diabetics with Metabolic Syndrome 1,4 [1,2–1,6] as compared with non-diabetic in absence of Metabolic Syndrome (p