A double-blind, dose-response study of losartan in hypertensive children

The aim of this study was to determine the dose-response relationship for losartan, 2.5 to 100 mg, and to assess the safety and tolerability of losartan in hypertensive children 6 to 16 years of age. This was a multicenter, randomized, double-blind, dose-response study. In Period 1, a total of 175 p...

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Veröffentlicht in:	American journal of hypertension 2005-02, Vol.18 (2), p.183-190
Hauptverfasser:	Shahinfar, Shahnaz, Cano, Francisco, Soffer, Beth A., Ahmed, Tuli, Santoro, Emanuela P., Zhang, Zhongxin, Gleim, Gilbert, Miller, Kenneth, Vogt, Beth, Blumer, Jeffrey, Briazgounov, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent angiotensin II receptor antagonist Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensive Agents - therapeutic use antihypertensives Blood Pressure - drug effects Body Weight Child children dose-response relationship Dose-Response Relationship, Drug Double-Blind Method Female Humans Hypertension Hypertension - drug therapy Hypertension - pathology Hypertension - physiopathology losartan Losartan - administration & dosage Losartan - adverse effects Losartan - therapeutic use Male pediatric safety
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Beschreibung
Zusammenfassung:	The aim of this study was to determine the dose-response relationship for losartan, 2.5 to 100 mg, and to assess the safety and tolerability of losartan in hypertensive children 6 to 16 years of age. This was a multicenter, randomized, double-blind, dose-response study. In Period 1, a total of 175 patients were stratified by weight (
ISSN:	0895-7061 1879-1905 1941-7225
DOI:	10.1016/j.amjhyper.2004.09.009