P-151: Correlation between estimated glomerular filtration rate and microalbuminuria in treated essential hypertensive patients

JNC-7 recognizes a moderately decreased estimated glomerular filtration rate (eGFR) and the finding of microalbuminuria (MA) as major independent cardiovascular (CV) risk factors. MA can be detected all over the range of eGFR values (from hyperfiltration to renal insufficiency). However, whether the increased CV risk associated to progressive reductions in eGFR is or not related to changes in MA is not completely known. Our aim was to analyze the correlation between MA and different levels of GFR (moderate decrease < 60; mild decreased 60–90, and normal >90 ml/min/1.73 m2) estimated by creatinine clearance, after adjusting for known variables influencing urinary albumin excretion. 2.221 essential hypertensive patients consecutively attended in our hypertension unit, were included in a cross-sectional study. The mean age was 60.4 (12.5 SD) years, 54.3% female, the average body mass index (BMI) 29.9 (5.1) kg/m2. The average blood pressure systolic/diastolic was 140 (26)/81 (10) mmHg. MA was significantly associated with moderate decreased eGFR (37.6%, see table); diabetes mellitus (42.4%), male gender (36.4%), older age (33.2%), and the presence of target organ damage or CV disease (39.6%). In a multiple logistic regression analysis MA was independently related with age, male gender, BMI, systolic BP, diabetes mellitus and eGFR. However, when the same analysis was performed excluding patients with moderate decreased eGFR, only eGFR did not maintain the association with positive MA. Stratified analysis by sex, age, and presence of diabetes showed similar results. eGFR (ml/min/1.73m2) N (%) MA prevalence (%) MA quantitative (mg/24h) (SD) >90 680 (65) 31.9 32.2 (85) 60–90 240 (23) 30.2 37.4 (125)