Sertraline-Induced Hyponatremia and Seizures in Old Age

To the Editor: Numerous case reports and observational studies have reported hyponatremia associated with selective serotonin reuptake inhibitor (SSRI) use.1 Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is postulated to be the cause of hyponatremia with SSRIs.2 Here, we present the case of an elderly gentleman developing hyponatremia and generalized convulsions immediately after initiation of sertraline treatment. [...]a close and serial monitoring of the sodium levels in patients with this profile is essential to prevent this adverse condition.