Remarkably High Rate of DNA Amplification Promoted by the Mating-Type Switching Mechanismin Schizosaccharomyces pombe

Remarkably High Rate of DNA Amplification Promoted by the Mating-Type Switching Mechanismin Schizosaccharomyces pombe

A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and...

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Veröffentlicht in:Genetics (Austin) 2012-05, Vol.191 (1), p.285
Hauptverfasser: Yu, Chuanhe, Bonaduce, Michael J, S Klar, Amar J
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Sprache:eng
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Deoxyribonucleic acid
DNA
Genomes
Mutation
Yeast
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S Klar, Amar J
description A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion. [PUBLICATION ABSTRACT]
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source Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Deoxyribonucleic acid
DNA
Genomes
Mutation
Yeast
title Remarkably High Rate of DNA Amplification Promoted by the Mating-Type Switching Mechanismin Schizosaccharomyces pombe
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