Remarkably High Rate of DNA Amplification Promoted by the Mating-Type Switching Mechanismin Schizosaccharomyces pombe

Remarkably High Rate of DNA Amplification Promoted by the Mating-Type Switching Mechanismin Schizosaccharomyces pombe

A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and...

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Veröffentlicht in:Genetics (Austin) 2012-05, Vol.191 (1), p.285
Hauptverfasser: Yu, Chuanhe, Bonaduce, Michael J, S Klar, Amar J
Format: Artikel
Sprache:eng
Schlagworte:
Deoxyribonucleic acid
DNA
Genomes
Mutation
Yeast
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Zusammenfassung:A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion. [PUBLICATION ABSTRACT]
ISSN:0016-6731
1943-2631