Rli1 does the splits

Eggleston discusses a study by Shoemaker and Green in which they reconstituted the yeast translation system in vitro and defined parallel roles for Rli1 in ribosome recycling, with both the classical termination factors eRF1-eRF3 and their paralogs Dom34-Hbs1. Their work illustrates several mechanistic distinctions between bacterial and eukaryotic ribosomal subunit recycling, and it suggests that eukaryotic recycling is more of a continuum than a highly delineated process.