Antimicrobial activity of mechanochemically synthesized composites of antibiotics and nanostructured silicon dioxide

Currently, cephalosporin antibiotics are among the most widely used drugs for antimicrobial therapy. The aim of this study was to obtain and perform a comparative study of antimicrobial activity and some physicochemical properties of the formulations of antibiotics of the cephalosporin group with na...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2012-04, Vol.443 (1), p.61-63
Hauptverfasser:	Dushkin, A. V., Gaidul’, K. V., Gol’dina, I. A., Gus’kov, S. A., Evseenko, V. I., Lyakhov, N. Z., Kozlov, V. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibiotics Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology Chemistry, Pharmaceutical Disease Models, Animal Dose-Response Relationship, Drug Drug Design Escherichia coli - drug effects Life Sciences Mice Mice, Inbred C57BL Nanostructured materials Nanostructures - chemistry Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - pathogenicity Sepsis - drug therapy Sepsis - microbiology Sepsis - mortality Silica Silicon Dioxide - chemistry Staphylococcus aureus - drug effects
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Beschreibung
Zusammenfassung:	Currently, cephalosporin antibiotics are among the most widely used drugs for antimicrobial therapy. The aim of this study was to obtain and perform a comparative study of antimicrobial activity and some physicochemical properties of the formulations of antibiotics of the cephalosporin group with nanostructured colloidal silica particles, which served as a drug carrier.
ISSN:	1607-6729 1608-3091
DOI:	10.1134/S1607672912020019