Stressed tumor cell, chemosensitized cancer

miR-200 family expression results in highly proliferative ovarian cancer cells. Yet this expression is also linked to longer overall survival in women with ovarian cancer. A new study sheds light into this apparent paradox showing that two members of this family—miR-141 and miR-200a—not only boost t...

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Veröffentlicht in:	Nature medicine 2011-12, Vol.17 (12), p.1552-1554
1. Verfasser:	Wiemer, Erik A C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/384/331 631/67/1059/99 692/699/67/1517/1709 Animals Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Ovarian Epithelial Cell growth Cell Transformation, Neoplastic - genetics Female Gene expression Humans Infectious Diseases Medical prognosis Metabolic Diseases MicroRNAs - genetics Molecular Medicine Neoplasms, Glandular and Epithelial - genetics Neurosciences news-and-views Ovarian cancer Ovarian Neoplasms - genetics Oxidative Stress Ribonucleic acid RNA
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Zusammenfassung:	miR-200 family expression results in highly proliferative ovarian cancer cells. Yet this expression is also linked to longer overall survival in women with ovarian cancer. A new study sheds light into this apparent paradox showing that two members of this family—miR-141 and miR-200a—not only boost tumor growth but also sensitize tumor cells to chemotherapy (pages 1627–1635 ).
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm.2593