Disentangling the MYC Web

Disentangling the MYC Web

Disordered MYC expression alters cell proliferation, cell growth, differentiation, and metabolism, but how MYC provokes this panoply of cellular pathology has been debated for years. Levens comments on a study that points to a complex web of direct MYC targets regulating metabolic flux and informati...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2002-04, Vol.99 (9), p.5757-5759
1. Verfasser: Levens, David
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis
Cancer
Cell cycle
Cell Division
Cell growth
Cells
Commentaries
Daughter cells
Gene Expression Regulation
Genes
Human umbilical vein endothelial cells
Humans
Models, Biological
Pathology
Proto-Oncogene Proteins c-myc - metabolism
Proto-Oncogene Proteins c-myc - physiology
RNA
Signal Transduction
Somatic cells
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Beschreibung
Zusammenfassung:Disordered MYC expression alters cell proliferation, cell growth, differentiation, and metabolism, but how MYC provokes this panoply of cellular pathology has been debated for years. Levens comments on a study that points to a complex web of direct MYC targets regulating metabolic flux and information streams through normal and transformed cells.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.102173199