UV-Induced Replication Arrest in the Xeroderma Pigmentosum Variant Leads to DNA Double-Strand Breaks, γ-H2AX Formation, and Mre11 Relocalization

UV-induced replication arrest in the xeroderma pigmentosum variant (XPV) but not in normal cells leads to an accumulation of the Mre11/Rad50/Nbs1 complex and phosphorylated histone H2AX (γ-H2AX) in large nuclear foci at sites of stalled replication forks. These complexes have been shown to signal th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-01, Vol.99 (1), p.233-238
Hauptverfasser:	Limoli, Charles L., Giedzinski, Erich, Bonner, William M., Cleaver, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell lines Cell nucleus Cellular biology Delta cells Deoxyribonucleic acid DNA DNA Damage DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Endodeoxyribonucleases - metabolism Exodeoxyribonucleases - metabolism Fibroblasts - metabolism Genetics histone H2AX Histones Histones - chemistry Humans Irradiation Kinetics Lead Lesions Microscopy, Fluorescence Mre11 protein Nbs1 protein Neutrophils Protein Transport Rad50 protein Recombination, Genetic S Phase Saccharomyces cerevisiae Proteins Studies Time Factors Ultraviolet radiation Ultraviolet Rays X-Rays
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