Breaking the Affinity Ceiling for Antibodies and T Cell Receptors

Breaking the Affinity Ceiling for Antibodies and T Cell Receptors

The overall lesson from antibody and T cell receptor (TCR) in vitro affinity maturation is that mechanisms generating these molecules in vivo operate in an affinity regime far below the inherent potential of antibodies and TCR for ligand binding.

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Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2000-09, Vol.97 (20), p.10679-10681
Hauptverfasser: Foote, Jefferson, Eisen, Herman N.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies
Antibodies - immunology
Antibody Affinity
Antigens
B lymphocytes
Cellular biology
Commentaries
Epitopes
Humans
Immunity
Immunology
Molecules
Receptors
Receptors, Antigen, T-Cell - immunology
Saccharomyces cerevisiae
T cell antigen receptors
T lymphocytes
T-Lymphocytes - immunology
Yeasts
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Beschreibung
Zusammenfassung:The overall lesson from antibody and T cell receptor (TCR) in vitro affinity maturation is that mechanisms generating these molecules in vivo operate in an affinity regime far below the inherent potential of antibodies and TCR for ligand binding.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.97.20.10679