A Membrane Lipid Imbalance Plays a Role in the Phenotypic Expression of Cystic Fibrosis in cftr-/-Mice

A deficiency in essential fatty acid metabolism has been reported in plasma from patients with cystic fibrosis (CF). However, its etiology and role in the expression of disease is unknown. The objective of this study was to determine whether alterations in fatty acid metabolism are specific to CF-re...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-11, Vol.96 (24), p.13995-14000
Hauptverfasser:	Freedman, Steven D., Katz, Mark H., Parker, Eliza M., Laposata, Michael, Urman, Mark Y., Alvarez, Juan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Arachidonic Acid - metabolism Arachidonic Acid - physiology Biological Sciences Biosynthesis Cystic fibrosis Cystic Fibrosis - pathology Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cystic Fibrosis Transmembrane Conductance Regulator - physiology Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - metabolism Essential fatty acids Fatty acids Ileum Ileum - metabolism Ileum - pathology Intestinal Absorption Lipids Lipopolysaccharides - immunology Lipopolysaccharides - pharmacology Liver - metabolism Lung - metabolism Lung - pathology Lungs Membrane lipids Membrane Lipids - metabolism Membrane Lipids - physiology Membranes Metabolism Mice Mice, Inbred C57BL Mice, Knockout Pancreas Pancreas - metabolism Pancreas - pathology Pathology Phenotype Phospholipids Phospholipids - metabolism Phospholipids - physiology Pneumonia Pseudomonas - immunology
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