A Novel Function for Myc: Inhibition of C/EBP-Dependent Gene Activation

We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription f...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-06, Vol.93 (13), p.6635-6640
Hauptverfasser:	Mink, Sigrun, Mutschler, Bettina, Weiskirchen, Ralf, Bister, Klaus, Klempnauer, Karl-Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases Amino acids Animals Biochemistry Cancer CCAAT-Enhancer-Binding Proteins Cell growth Cell Line Cell lines Cells Chickens DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Down-Regulation Gene expression Gene Expression Regulation - physiology Genes Muramidase - genetics Nuclear Proteins - genetics Oncogene Protein p55(v-myc) - chemistry Oncogene Protein p55(v-myc) - physiology Plasmids Proteins Proteins - genetics Quail Transactivation Transcription factors Transcriptional Activation
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