A Novel Function for Myc: Inhibition of C/EBP-Dependent Gene Activation
We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription f...
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Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1996-06, Vol.93 (13), p.6635-6640 |
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Sprache: | eng |
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Zusammenfassung: | We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present evidence that Myc down-regulates these genes by inhibiting the function of C/EBP transcription factors. Detailed examination of the inhibitory mechanism shows that amino-terminal sequences of v-Myc, but not its DNA-binding domain, are required for the suppression of C/EBP-dependent transactivation. Our findings identify a new function for Myc and reveal a novel mechanism by which Myc affects the expression of other genes. |
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ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.93.13.6635 |