Simultaneous Visualization of Chromosome Bands and Hybridization Signal Using Colloidal-Gold Labeling in Electron Microscopy

Electron microscopy (EM) is seldom used with in situ hybridization to localize DNA sequences because banding methods for chromosome identification could not be coupled to EM techniques. We have applied an immunochemical replication-banding method specific for EM to solve this problem. A thymidine sy...

Ausführliche Beschreibung