Induction of c-sis mRNA and Activity Similar to Platelet-Derived Growth Factor by Transforming Growth Factor β : A Proposed Model for Indirect Mitogenesis Involving Autocrine Activity
Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor β resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium....
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1986-04, Vol.83 (8), p.2453-2457 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 83 |
| creator | Leof, Edward B. Proper, Jacqueline A. Goustin, Anton Scott Shipley, Gary D. DiCorleto, Paul E. Moses, Harold L. |
| description | Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor β resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDGF-regulated genes (c-fos and c-myc) were stimulated by transforming growth factor β with delayed kinetics relative to that seen in other cell systems with direct PDGF stimulation. A model is proposed in which the monolayer mitogenicity of transforming growth factor β is mediated by the induction of c-sis and PDGF and the subsequent autocrine stimulation of c-fos, c-myc, and other PDGF-inducible genes. |
| doi_str_mv | 10.1073/pnas.83.8.2453 |
| format | Article |
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The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDGF-regulated genes (c-fos and c-myc) were stimulated by transforming growth factor β with delayed kinetics relative to that seen in other cell systems with direct PDGF stimulation. A model is proposed in which the monolayer mitogenicity of transforming growth factor β is mediated by the induction of c-sis and PDGF and the subsequent autocrine stimulation of c-fos, c-myc, and other PDGF-inducible genes.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.83.8.2453</identifier><identifier>PMID: 3010310</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>3T3 cells ; Animals ; Biological and medical sciences ; Cell culture techniques ; Cell Cycle - drug effects ; Cell growth ; Cell physiology ; Cells ; Cells, Cultured ; Cultured cells ; Epithelial cells ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; Humans ; Kinetics ; Messenger RNA ; Mice ; Mitosis - drug effects ; Molecular and cellular biology ; Peptides - pharmacology ; Platelet-Derived Growth Factor - biosynthesis ; Platelet-Derived Growth Factor - genetics ; Proto-Oncogene Proteins - genetics ; Proto-Oncogenes ; Receptors, Cell Surface - metabolism ; Receptors, Platelet-Derived Growth Factor ; Responses to growth factors, tumor promotors, other factors ; RNA ; sis genes ; Transcription, Genetic - drug effects ; Transforming Growth Factors</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1986-04, Vol.83 (8), p.2453-2457</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4663-ca6eda720b14367d77bef3b5310f2650a37df7d5b9c01fe037e3168000992f503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/83/8.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27302$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27302$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8698985$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3010310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leof, Edward B.</creatorcontrib><creatorcontrib>Proper, Jacqueline A.</creatorcontrib><creatorcontrib>Goustin, Anton Scott</creatorcontrib><creatorcontrib>Shipley, Gary D.</creatorcontrib><creatorcontrib>DiCorleto, Paul E.</creatorcontrib><creatorcontrib>Moses, Harold L.</creatorcontrib><title>Induction of c-sis mRNA and Activity Similar to Platelet-Derived Growth Factor by Transforming Growth Factor β : A Proposed Model for Indirect Mitogenesis Involving Autocrine Activity</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor β resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDGF-regulated genes (c-fos and c-myc) were stimulated by transforming growth factor β with delayed kinetics relative to that seen in other cell systems with direct PDGF stimulation. A model is proposed in which the monolayer mitogenicity of transforming growth factor β is mediated by the induction of c-sis and PDGF and the subsequent autocrine stimulation of c-fos, c-myc, and other PDGF-inducible genes.</description><subject>3T3 cells</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell culture techniques</subject><subject>Cell Cycle - drug effects</subject><subject>Cell growth</subject><subject>Cell physiology</subject><subject>Cells</subject><subject>Cells, Cultured</subject><subject>Cultured cells</subject><subject>Epithelial cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Messenger RNA</subject><subject>Mice</subject><subject>Mitosis - drug effects</subject><subject>Molecular and cellular biology</subject><subject>Peptides - pharmacology</subject><subject>Platelet-Derived Growth Factor - biosynthesis</subject><subject>Platelet-Derived Growth Factor - genetics</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogenes</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Platelet-Derived Growth Factor</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>RNA</subject><subject>sis genes</subject><subject>Transcription, Genetic - drug effects</subject><subject>Transforming Growth Factors</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFu1DAYhCMEKkvhygEJyQfELcGJk9hB4hAVWlZqoYJythzH3rpy7MV2AvtanHgKnglHu0QL4pTDNzP_OJMkT3OY5RCjV1vDfEZQRrKirNC9ZJXDJk_rsoH3kxWEBU5JWZQPk0fe30EIm4rAk-QEwRyiHK6Sn2vTjzwoa4CVgKdeeTB8-tACZnrQRjCpsAOf1aA0cyBYcK1ZEFqE9K1wahI9uHD2W7gF54wH60C3AzeOGS-tG5TZ_EN__QCvQQuund1aH71XthcaRC2INZQTPIArFexGGDEXWZvJ6mmOacdguVNGLJ0eJw8k0148OXxPky_n727O3qeXHy_WZ-1lysu6RilntegZLmCXl6jGPcadkKir4uNlUVeQIdxL3Fddw2EuBURYoLwm859qCllBdJq82edux24QPRcmOKbp1qmBuR21TNG_iVG3dGMnigoUk6L_5cHv7NdR-EAH5bnQmhlhR09xTQqIySzM9kLurPdOyOVGDuk8NZ2npgRRQuepo-H5cbNFftg28hcHzjxnWsZZuPKLjNQNaUh1VHCOX-ifM1SOWgfxPRzd-68w8md7fufj1ougwAgW6DfkqNZc</recordid><startdate>19860401</startdate><enddate>19860401</enddate><creator>Leof, Edward B.</creator><creator>Proper, Jacqueline A.</creator><creator>Goustin, Anton Scott</creator><creator>Shipley, Gary D.</creator><creator>DiCorleto, Paul E.</creator><creator>Moses, Harold L.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19860401</creationdate><title>Induction of c-sis mRNA and Activity Similar to Platelet-Derived Growth Factor by Transforming Growth Factor β : A Proposed Model for Indirect Mitogenesis Involving Autocrine Activity</title><author>Leof, Edward B. ; Proper, Jacqueline A. ; Goustin, Anton Scott ; Shipley, Gary D. ; DiCorleto, Paul E. ; Moses, Harold L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4663-ca6eda720b14367d77bef3b5310f2650a37df7d5b9c01fe037e3168000992f503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>3T3 cells</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell culture techniques</topic><topic>Cell Cycle - drug effects</topic><topic>Cell growth</topic><topic>Cell physiology</topic><topic>Cells</topic><topic>Cells, Cultured</topic><topic>Cultured cells</topic><topic>Epithelial cells</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Messenger RNA</topic><topic>Mice</topic><topic>Mitosis - drug effects</topic><topic>Molecular and cellular biology</topic><topic>Peptides - pharmacology</topic><topic>Platelet-Derived Growth Factor - biosynthesis</topic><topic>Platelet-Derived Growth Factor - genetics</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogenes</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Platelet-Derived Growth Factor</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>RNA</topic><topic>sis genes</topic><topic>Transcription, Genetic - drug effects</topic><topic>Transforming Growth Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leof, Edward B.</creatorcontrib><creatorcontrib>Proper, Jacqueline A.</creatorcontrib><creatorcontrib>Goustin, Anton Scott</creatorcontrib><creatorcontrib>Shipley, Gary D.</creatorcontrib><creatorcontrib>DiCorleto, Paul E.</creatorcontrib><creatorcontrib>Moses, Harold L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leof, Edward B.</au><au>Proper, Jacqueline A.</au><au>Goustin, Anton Scott</au><au>Shipley, Gary D.</au><au>DiCorleto, Paul E.</au><au>Moses, Harold L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of c-sis mRNA and Activity Similar to Platelet-Derived Growth Factor by Transforming Growth Factor β : A Proposed Model for Indirect Mitogenesis Involving Autocrine Activity</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1986-04-01</date><risdate>1986</risdate><volume>83</volume><issue>8</issue><spage>2453</spage><epage>2457</epage><pages>2453-2457</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Treatment of quiescent cultures of mouse embryo-derived AKR-2B cells with transforming growth factor β resulted in an early induction of c-sis mRNA. The increase in c-sis mRNA was followed by a corresponding increase in protein similar to platelet-derived growth factor (PDGF) in the culture medium. In addition, PDGF-regulated genes (c-fos and c-myc) were stimulated by transforming growth factor β with delayed kinetics relative to that seen in other cell systems with direct PDGF stimulation. A model is proposed in which the monolayer mitogenicity of transforming growth factor β is mediated by the induction of c-sis and PDGF and the subsequent autocrine stimulation of c-fos, c-myc, and other PDGF-inducible genes.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>3010310</pmid><doi>10.1073/pnas.83.8.2453</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1986-04, Vol.83 (8), p.2453-2457 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_83_8_2453 |
| source | MEDLINE; Full-Text Journals in Chemistry (Open access); PubMed Central; Alma/SFX Local Collection; JSTOR |
| subjects | 3T3 cells Animals Biological and medical sciences Cell culture techniques Cell Cycle - drug effects Cell growth Cell physiology Cells Cells, Cultured Cultured cells Epithelial cells Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Humans Kinetics Messenger RNA Mice Mitosis - drug effects Molecular and cellular biology Peptides - pharmacology Platelet-Derived Growth Factor - biosynthesis Platelet-Derived Growth Factor - genetics Proto-Oncogene Proteins - genetics Proto-Oncogenes Receptors, Cell Surface - metabolism Receptors, Platelet-Derived Growth Factor Responses to growth factors, tumor promotors, other factors RNA sis genes Transcription, Genetic - drug effects Transforming Growth Factors |
| title | Induction of c-sis mRNA and Activity Similar to Platelet-Derived Growth Factor by Transforming Growth Factor β : A Proposed Model for Indirect Mitogenesis Involving Autocrine Activity |
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