Control of the Synthesis of Fatty-Acid Synthetase in Rat Liver by Insulin, Glucagon, and Adenosine 3′:5′Cyclic Monophosphate
The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon an...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1972-12, Vol.69 (12), p.3516-3519 |
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| container_end_page | 3519 |
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| container_issue | 12 |
| container_start_page | 3516 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 69 |
| creator | Lakshmanan, M. R. Nepokroeff, Carl M. Porter, John W. |
| description | The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon and cyclic AMP inhibit the increase in the activity of fatty-acid synthetase. Therefore, the concentration of fatty-acid synthetase in rat liver is under the control of the relative concentrations of insulin and glucagon. |
| doi_str_mv | 10.1073/pnas.69.12.3516 |
| format | Article |
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R.</creatorcontrib><creatorcontrib>Nepokroeff, Carl M.</creatorcontrib><creatorcontrib>Porter, John W.</creatorcontrib><title>Control of the Synthesis of Fatty-Acid Synthetase in Rat Liver by Insulin, Glucagon, and Adenosine 3′:5′Cyclic Monophosphate</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon and cyclic AMP inhibit the increase in the activity of fatty-acid synthetase. Therefore, the concentration of fatty-acid synthetase in rat liver is under the control of the relative concentrations of insulin and glucagon.</description><subject>Animals</subject><subject>Biological Sciences: Biochemistry</subject><subject>Body weight</subject><subject>Carbon Isotopes</subject><subject>Cyclic AMP - pharmacology</subject><subject>Diabetes</subject><subject>Diabetes complications</subject><subject>Diabetes Mellitus - enzymology</subject><subject>Diet</subject><subject>Enzyme Induction - drug effects</subject><subject>Enzymes</subject><subject>Fasting</subject><subject>Fatty Acid Synthases - biosynthesis</subject><subject>Glucagon - pharmacology</subject><subject>Human resources</subject><subject>Insulin</subject><subject>Insulin - pharmacology</subject><subject>Kinetics</subject><subject>Leucine - metabolism</subject><subject>Liver</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Rats</subject><subject>Refeeding</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EKtPCGgkJ5BVsyNR_iR0kFqMRLZUGIfGzthyP03HlsdPYqciuz9RH4klwNKGFDRtf657vXPvqAPACoyVGnJ52XsVlVS8xWdISV4_AAqMaFxWr0WOwQIjwQjDCnoLjGK8QQnUp0BE4YpSVJSILcLsOPvXBwdDCtDPw2-hziTZOjTOV0listN3O_aSigdbDryrBjb0xPWxGeOHj4Kx_B8_doNVlyDflt3C1NT5E6w2kv27v3pf5WI_aWQ0_Bx-6XYjdTiXzDDxplYvm-VxPwI-zj9_Xn4rNl_OL9WpT6JLwVGzzKg3mgrQcN7mja6waKhQzouWiZnn3hgvBeN1UFFPWEMbbiohK44rRUtMT8OEwtxuavdlqk9dWTna93at-lEFZ-a_i7U5ehhtJRS0wyv43s78P14OJSe5t1MY55U0YohSYI0wqnsHTA6j7EGNv2vs3MJJTZnLKTFa1xEROmWXHq7-_ds_PIWX97axPxj_qwwDZDs4l8zNl8vV_yQy8PABXMYX-gSCIlPQ3xtq2BQ</recordid><startdate>19721201</startdate><enddate>19721201</enddate><creator>Lakshmanan, M. 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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1972-12, Vol.69 (12), p.3516-3519 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_69_12_3516_fulltext |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological Sciences: Biochemistry Body weight Carbon Isotopes Cyclic AMP - pharmacology Diabetes Diabetes complications Diabetes Mellitus - enzymology Diet Enzyme Induction - drug effects Enzymes Fasting Fatty Acid Synthases - biosynthesis Glucagon - pharmacology Human resources Insulin Insulin - pharmacology Kinetics Leucine - metabolism Liver Liver - enzymology Male Rats Refeeding |
| title | Control of the Synthesis of Fatty-Acid Synthetase in Rat Liver by Insulin, Glucagon, and Adenosine 3′:5′Cyclic Monophosphate |
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