Control of the Synthesis of Fatty-Acid Synthetase in Rat Liver by Insulin, Glucagon, and Adenosine 3′:5′Cyclic Monophosphate

The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon an...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1972-12, Vol.69 (12), p.3516-3519
Hauptverfasser:	Lakshmanan, M. R., Nepokroeff, Carl M., Porter, John W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences: Biochemistry Body weight Carbon Isotopes Cyclic AMP - pharmacology Diabetes Diabetes complications Diabetes Mellitus - enzymology Diet Enzyme Induction - drug effects Enzymes Fasting Fatty Acid Synthases - biosynthesis Glucagon - pharmacology Human resources Insulin Insulin - pharmacology Kinetics Leucine - metabolism Liver Liver - enzymology Male Rats Refeeding
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Beschreibung
Zusammenfassung:	The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon and cyclic AMP inhibit the increase in the activity of fatty-acid synthetase. Therefore, the concentration of fatty-acid synthetase in rat liver is under the control of the relative concentrations of insulin and glucagon.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.69.12.3516