A Mouse Atlas of Gene Expression: Large-Scale Digital Gene-Expression Profiles from Precisely Defined Developing C57BL/6J Mouse Tissues and Cells

We analyzed 8.55 million LongSAGE tags generated from 72 libraries. Each LongSAGE library was prepared from a different mouse tissue. Analysis of the data revealed extensive overlap with existing gene data sets and evidence for the existence of ≈ 24,000 previously undescribed genomic loci. The visua...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-12, Vol.102 (51), p.18485-18490
Hauptverfasser:	Asim S. Siddiqui, Khattra, Jaswinder, Allen D. Delaney, Yongjun Zhao, Caroline Astell, Jennifer Asano, Ryan Babakaiff, Barber, Sarah, Jaclyn Beland, Slavita Bohacec, Mabel Brown-John, Steve Chand, David Charest, Anita M. Charters, Rebecca Cullum, Noreen Dhalla, Ruth Featherstone, Gerhard, Daniela S., Brad Hoffman, Holt, Robert A., Juan Hou, Byron Y. -L. Kuo, Lisa L. C. Lee, Stephanie Lee, Derek Leung, Kevin Ma, Corey Matsuo, Mayo, Michael, McDonald, Helen, Anna-Iiisa Prabhu, Pawan Pandoh, Riggins, Gregory J., Teresa Ruiz de Algara, James L. Rupert, Duane Smailus, Jeff Stott, Miranda Tsai, Richard Varhol, Pavle Vrljicak, Wong, David, Mona K. Wu, Yuan-Yun Xie, George Yang, Ida Zhang, Hirst, Martin, Steven J. M. Jones, Helgason, Cheryl D., Simpson, Elizabeth M., Pamela A. Hoodless, Marra, Marco A., Waterston, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Animals Biological Sciences Exons Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental - genetics Genes Genetic loci Genomes Genomics Libraries Mice - genetics Mice, Inbred C57BL - genetics Multigene Family - genetics Reproducibility of Results RNA RNA, Untranslated - genetics Rodents Transcription, Genetic - genetics Untranslated regions
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Zusammenfassung:	We analyzed 8.55 million LongSAGE tags generated from 72 libraries. Each LongSAGE library was prepared from a different mouse tissue. Analysis of the data revealed extensive overlap with existing gene data sets and evidence for the existence of ≈ 24,000 previously undescribed genomic loci. The visual cortex, pancreas, mammary gland, preimplantation embryo, and placenta contain the largest number of differentially expressed transcripts, 25% of which are previously undescribed loci.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.0509455102