A Nucleophile-Catalyzed Cycloisomerization Permits a Concise Synthesis of (+)-Harziphilone
Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphi...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (33), p.12064-12066 |
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| container_end_page | 12066 |
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| container_issue | 33 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 101 |
| creator | Stark, Lucy M. Pekari, Klaus Sorensen, Erik J. Nicolaou, Kyriacos C. |
| description | Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphilone under mild reaction conditions. |
| doi_str_mv | 10.1073/pnas.0402563101 |
| format | Article |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Alcohols Aldehydes Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Benzopyrans - chemical synthesis Benzopyrans - chemistry Carbon Catalysis Catalysts Chemical reactions Chemical synthesis Chemistry Chemistry, Organic - methods Diones HIV 1 Human immunodeficiency virus 1 Molecular Structure Molecules Natural Product Synthesis Special Feature Nucleophiles Physical Sciences Piperazines Reactivity Room temperature Stereoisomerism |
| title | A Nucleophile-Catalyzed Cycloisomerization Permits a Concise Synthesis of (+)-Harziphilone |
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