A Nucleophile-Catalyzed Cycloisomerization Permits a Concise Synthesis of (+)-Harziphilone

Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (33), p.12064-12066
Hauptverfasser:	Stark, Lucy M., Pekari, Klaus, Sorensen, Erik J., Nicolaou, Kyriacos C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Aldehydes Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Benzopyrans - chemical synthesis Benzopyrans - chemistry Carbon Catalysis Catalysts Chemical reactions Chemical synthesis Chemistry Chemistry, Organic - methods Diones HIV 1 Human immunodeficiency virus 1 Molecular Structure Molecules Natural Product Synthesis Special Feature Nucleophiles Physical Sciences Piperazines Reactivity Room temperature Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphilone under mild reaction conditions.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.0402563101