Plasma Fibronectin Promotes Thrombus Growth and Stability in Injured Arterioles

Mice lacking both of the best-known platelet ligands, von Willebrand factor and fibrinogen, can still form occlusive thrombi in injured arterioles. The platelets of these animals accumulate excessive amounts of fibronectin (FN). These observations led us to examine the contribution of plasma FN (pFN...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-03, Vol.100 (5), p.2415-2419
Hauptverfasser:	Ni, Heyu, Peter S. T. Yuen, Papalia, Jessie M., Trevithick, Jane E., Sakai, Takao, Fässler, Reinhard, Hynes, Richard O., Wagner, Denisa D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterioles Arterioles - physiology Biological Sciences Blood Blood plasma Blood Platelets - cytology Blood Platelets - metabolism Blood vessels Blotting, Western Cell Adhesion Cellular biology Fibronectins - blood Fibronectins - metabolism Genotype Integrins Mice Mice, Transgenic Physical trauma Plasma Plasma stability Platelet Adhesiveness - physiology Platelet Aggregation - physiology Platelets Thrombosis Thrombosis - blood Thrombosis - etiology von Willebrand Factor - metabolism
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Zusammenfassung:	Mice lacking both of the best-known platelet ligands, von Willebrand factor and fibrinogen, can still form occlusive thrombi in injured arterioles. The platelets of these animals accumulate excessive amounts of fibronectin (FN). These observations led us to examine the contribution of plasma FN (pFN) to thrombus formation. Inactivation of the FN gene in FN conditional knockout mice reduced pFN levels to
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.2628067100