Glycemia reduction in type 2 diabetes-Hypoglycemia outcomes: A randomized clinical trial

Hypoglycemia is a major concern in type 2 diabetes (T2DM), but little is known about its likelihood compared across common therapies. We compared the likelihood of hypoglycemia among metformin-treated patients with T2DM randomized to the addition of one of 4 common therapies. Randomized, controlled...

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Veröffentlicht in:	PloS one 2024-11, Vol.19 (11), p.e0309907
Hauptverfasser:	Seaquist, Elizabeth R, Phillips, Lawrence S, Ghosh, Alokananda, Baker, Chelsea, Bergenstal, Richard M, Crandall, Jill P, Goland, Robin S, Gramzinski, Michaela R, Hox, Sophia H, Hsia, Daniel S, Johnson, Mary L, Lachin, John M, Raskin, Philip, Valencia, Willy M, Waltje, Andrea H, Younes, Naji
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood glucose Blood Glucose - analysis Blood Glucose - drug effects Body mass index Complications and side effects Development and progression Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diagnosis Drug dosages Drug therapy Female Glucose Glycated Hemoglobin - analysis Glycated Hemoglobin - metabolism Glycemic Control Hemoglobin Humans Hypoglycemia Hypoglycemia - chemically induced Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Insulin Insulin Glargine - administration & dosage Insulin Glargine - adverse effects Insulin Glargine - therapeutic use Liraglutide - adverse effects Liraglutide - therapeutic use Male Metformin Metformin - adverse effects Metformin - therapeutic use Middle Aged Probability Randomization Research design Review boards Risk factors Sitagliptin Phosphate - adverse effects Sitagliptin Phosphate - therapeutic use Sulfonylurea Compounds - adverse effects Sulfonylurea Compounds - therapeutic use Treatment Outcome Type 2 diabetes
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Zusammenfassung:	Hypoglycemia is a major concern in type 2 diabetes (T2DM), but little is known about its likelihood compared across common therapies. We compared the likelihood of hypoglycemia among metformin-treated patients with T2DM randomized to the addition of one of 4 common therapies. Randomized, controlled trial of 5,047 participants with T2DM of
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0309907