HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983-2015

HIV replication leads to a change in lymphocyte phenotypes that impairs immune protection against opportunistic infections. We examined current HIV replication as an independent risk factor for tuberculosis (TB). We included people living with HIV from 25 European cohorts 1983-2015. Individuals

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Veröffentlicht in:	PloS one 2024-10, Vol.19 (10), p.e0312035
Hauptverfasser:	Atkinson, Andrew, Kraus, David, Banholzer, Nicolas, Miro, Jose M, Reiss, Peter, Kirk, Ole, Mussini, Cristina, Morlat, Philippe, Podlekareva, Daria, Grant, Alison D, Sabin, Caroline, van der Valk, Marc, Le Moing, Vincent, Meyer, Laurence, Seng, Remonie, Castagna, Antonella, Obel, Niels, Antoniadou, Anastasia, Salmon, Dominique, Zwahlen, Marcel, Egger, Matthias, de Wit, Stephane, Furrer, Hansjakob, Fenner, Lukas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS CD4 antigen CD4 Lymphocyte Count Cohort Studies Collaboration Confidence intervals Epidemiology Ethics Europe - epidemiology Female Gender Geography Heterosexuality HIV HIV Infections - complications HIV Infections - epidemiology HIV Infections - immunology HIV patients Human immunodeficiency virus Humans Immune system Incidence Infections Life Sciences Lymphocytes Male Medical research Medicine, Experimental Middle Aged Patients Phenotypes Public health Regression analysis Regression models Replication Ribonucleic acid Risk Factors RNA RNA, Viral Santé publique et épidémiologie Statistical analysis Statistics Tuberculosis Tuberculosis - epidemiology Tuberculosis - immunology Virus Replication
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Zusammenfassung:	HIV replication leads to a change in lymphocyte phenotypes that impairs immune protection against opportunistic infections. We examined current HIV replication as an independent risk factor for tuberculosis (TB). We included people living with HIV from 25 European cohorts 1983-2015. Individuals
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0312035