Design and implementation of corrosion-resistant multitasking cell stainers
Compared with machine staining, traditional manual staining faces various problems, such as a low preparation success rate, low efficiency, and harm to the human body due to corrosive gases. Therefore, a stainer that is of low cost, has strong corrosion resistance, and is suitable for small-batch pr...
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description | Compared with machine staining, traditional manual staining faces various problems, such as a low preparation success rate, low efficiency, and harm to the human body due to corrosive gases. Therefore, a stainer that is of low cost, has strong corrosion resistance, and is suitable for small-batch preparation should be developed. In this study, by choosing a rotary scheme as the structural basis, a reusable container cover and a master-slave manipulator cooperation scheme are developed, which greatly improve the space utilization rate. Through material selection and structural design, in the designed stainer, effective protection against strong acids with high volatility and permeability is realized, thereby eliminating the corrosion issue. Using the designed splitting-running algorithm for the dyeing procedure, simultaneous multistaining is realized, which significantly improves the staining efficiency. Compared with large-sized stainers, the cost of the proposed stainer is very low, which will help popularize early screening for cervical cancer in low- and middle-income countries. |
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Therefore, a stainer that is of low cost, has strong corrosion resistance, and is suitable for small-batch preparation should be developed. In this study, by choosing a rotary scheme as the structural basis, a reusable container cover and a master-slave manipulator cooperation scheme are developed, which greatly improve the space utilization rate. Through material selection and structural design, in the designed stainer, effective protection against strong acids with high volatility and permeability is realized, thereby eliminating the corrosion issue. Using the designed splitting-running algorithm for the dyeing procedure, simultaneous multistaining is realized, which significantly improves the staining efficiency. Compared with large-sized stainers, the cost of the proposed stainer is very low, which will help popularize early screening for cervical cancer in low- and middle-income countries.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0309334</identifier><identifier>PMID: 39388425</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Algorithms ; Biology and Life Sciences ; Care and treatment ; Cellular biology ; Cervical cancer ; Coloring Agents - chemistry ; Cooperation ; Corrosion ; Corrosion cell ; Corrosion prevention ; Corrosion rate ; Corrosion resistance ; Corrosion tests ; Cytodiagnosis ; Design ; Diagnosis ; Dyes ; Engineering and Technology ; Equipment Design ; Evaluation ; Gases ; Human papillomavirus ; Humans ; Laboratories ; Liquor ; Low income groups ; Materials selection ; Medicine and Health Sciences ; Multitasking ; Physical Sciences ; Pyrrhocoridae ; Research and Analysis Methods ; Staining ; Staining and Labeling - methods ; Structural design ; Structural engineering</subject><ispartof>PloS one, 2024-10, Vol.19 (10), p.e0309334</ispartof><rights>Copyright: © 2024 Liao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Liao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Liao et al 2024 Liao et al</rights><rights>2024 Liao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c460t-a1947e8972a2841bdd3727d3ca7805e264c3d9e550cd851db0660afee7e14dd03</cites><orcidid>0009-0007-7859-8072</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466404/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466404/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39388425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Chengsheng</creatorcontrib><creatorcontrib>Gong, Zhen</creatorcontrib><creatorcontrib>Fang, Run</creatorcontrib><creatorcontrib>Li, Leheng</creatorcontrib><creatorcontrib>Gao, Zhifan</creatorcontrib><creatorcontrib>Mao, Min</creatorcontrib><creatorcontrib>Zeng, Libo</creatorcontrib><title>Design and implementation of corrosion-resistant multitasking cell stainers</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Compared with machine staining, traditional manual staining faces various problems, such as a low preparation success rate, low efficiency, and harm to the human body due to corrosive gases. Therefore, a stainer that is of low cost, has strong corrosion resistance, and is suitable for small-batch preparation should be developed. In this study, by choosing a rotary scheme as the structural basis, a reusable container cover and a master-slave manipulator cooperation scheme are developed, which greatly improve the space utilization rate. Through material selection and structural design, in the designed stainer, effective protection against strong acids with high volatility and permeability is realized, thereby eliminating the corrosion issue. Using the designed splitting-running algorithm for the dyeing procedure, simultaneous multistaining is realized, which significantly improves the staining efficiency. Compared with large-sized stainers, the cost of the proposed stainer is very low, which will help popularize early screening for cervical cancer in low- and middle-income countries.</description><subject>Algorithms</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Cellular biology</subject><subject>Cervical cancer</subject><subject>Coloring Agents - chemistry</subject><subject>Cooperation</subject><subject>Corrosion</subject><subject>Corrosion cell</subject><subject>Corrosion prevention</subject><subject>Corrosion rate</subject><subject>Corrosion resistance</subject><subject>Corrosion tests</subject><subject>Cytodiagnosis</subject><subject>Design</subject><subject>Diagnosis</subject><subject>Dyes</subject><subject>Engineering and Technology</subject><subject>Equipment Design</subject><subject>Evaluation</subject><subject>Gases</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Liquor</subject><subject>Low income groups</subject><subject>Materials selection</subject><subject>Medicine and Health Sciences</subject><subject>Multitasking</subject><subject>Physical Sciences</subject><subject>Pyrrhocoridae</subject><subject>Research and Analysis Methods</subject><subject>Staining</subject><subject>Staining and Labeling - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Chengsheng</au><au>Gong, Zhen</au><au>Fang, Run</au><au>Li, Leheng</au><au>Gao, Zhifan</au><au>Mao, Min</au><au>Zeng, Libo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design and implementation of corrosion-resistant multitasking cell stainers</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-10-10</date><risdate>2024</risdate><volume>19</volume><issue>10</issue><spage>e0309334</spage><pages>e0309334-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Compared with machine staining, traditional manual staining faces various problems, such as a low preparation success rate, low efficiency, and harm to the human body due to corrosive gases. Therefore, a stainer that is of low cost, has strong corrosion resistance, and is suitable for small-batch preparation should be developed. In this study, by choosing a rotary scheme as the structural basis, a reusable container cover and a master-slave manipulator cooperation scheme are developed, which greatly improve the space utilization rate. Through material selection and structural design, in the designed stainer, effective protection against strong acids with high volatility and permeability is realized, thereby eliminating the corrosion issue. Using the designed splitting-running algorithm for the dyeing procedure, simultaneous multistaining is realized, which significantly improves the staining efficiency. Compared with large-sized stainers, the cost of the proposed stainer is very low, which will help popularize early screening for cervical cancer in low- and middle-income countries.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39388425</pmid><doi>10.1371/journal.pone.0309334</doi><tpages>e0309334</tpages><orcidid>https://orcid.org/0009-0007-7859-8072</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Algorithms Biology and Life Sciences Care and treatment Cellular biology Cervical cancer Coloring Agents - chemistry Cooperation Corrosion Corrosion cell Corrosion prevention Corrosion rate Corrosion resistance Corrosion tests Cytodiagnosis Design Diagnosis Dyes Engineering and Technology Equipment Design Evaluation Gases Human papillomavirus Humans Laboratories Liquor Low income groups Materials selection Medicine and Health Sciences Multitasking Physical Sciences Pyrrhocoridae Research and Analysis Methods Staining Staining and Labeling - methods Structural design Structural engineering |
title | Design and implementation of corrosion-resistant multitasking cell stainers |
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