Design and implementation of corrosion-resistant multitasking cell stainers

Compared with machine staining, traditional manual staining faces various problems, such as a low preparation success rate, low efficiency, and harm to the human body due to corrosive gases. Therefore, a stainer that is of low cost, has strong corrosion resistance, and is suitable for small-batch pr...

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Veröffentlicht in:PloS one 2024-10, Vol.19 (10), p.e0309334
Hauptverfasser: Liao, Chengsheng, Gong, Zhen, Fang, Run, Li, Leheng, Gao, Zhifan, Mao, Min, Zeng, Libo
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Sprache:eng
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Zusammenfassung:Compared with machine staining, traditional manual staining faces various problems, such as a low preparation success rate, low efficiency, and harm to the human body due to corrosive gases. Therefore, a stainer that is of low cost, has strong corrosion resistance, and is suitable for small-batch preparation should be developed. In this study, by choosing a rotary scheme as the structural basis, a reusable container cover and a master-slave manipulator cooperation scheme are developed, which greatly improve the space utilization rate. Through material selection and structural design, in the designed stainer, effective protection against strong acids with high volatility and permeability is realized, thereby eliminating the corrosion issue. Using the designed splitting-running algorithm for the dyeing procedure, simultaneous multistaining is realized, which significantly improves the staining efficiency. Compared with large-sized stainers, the cost of the proposed stainer is very low, which will help popularize early screening for cervical cancer in low- and middle-income countries.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0309334