An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol

An international study to investigate and optimise the safety of discontinuing valproate in young men and women with epilepsy: Protocol

Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence extended this risk to men's offspring, prompting recommendations to restrict use in everybody aged

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Bibliographische Detailangaben
Veröffentlicht in:PloS one 2024-08, Vol.19 (8), p.e0306226
Hauptverfasser: Mbizvo, Gashirai K, Martin, Glen P, Sperrin, Matthew, Bonnett, Laura J, Schofield, Pieta, Buchan, Iain, Lip, Gregory Y H, Marson, Anthony G
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Anticonvulsants - adverse effects
Anticonvulsants - therapeutic use
Care and treatment
Codes
Computer and Information Sciences
Convulsions & seizures
Decision making
Demographic aspects
Divalproex
Dosage and administration
Epilepsy
Epilepsy - drug therapy
Etiracetam
Female
Hospitals
Humans
Hypotheses
International studies
Lamotrigine
Lamotrigine - adverse effects
Lamotrigine - therapeutic use
Levetiracetam - adverse effects
Levetiracetam - therapeutic use
Male
Medicine and Health Sciences
Middle Aged
Morbidity
Mortality
Offspring
Patient admissions
Patient outcomes
Patients
Physical Sciences
Prediction models
Predictions
Randomization
Research and Analysis Methods
Retrospective Studies
Study Protocol
Survival analysis
Teratogenicity
Valproic acid
Valproic Acid - adverse effects
Valproic Acid - therapeutic use
Womens health
Young Adult
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Beschreibung
Zusammenfassung:Valproate is the most effective treatment for idiopathic generalised epilepsy. Currently, its use is restricted in women of childbearing potential owing to high teratogenicity. Recent evidence extended this risk to men's offspring, prompting recommendations to restrict use in everybody aged
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0306226