First-year outcomes of very low birth weight preterm singleton infants with hypoxemic respiratory failure treated with milrinone and inhaled nitric oxide (iNO) compared to iNO alone: A nationwide retrospective study

First-year outcomes of very low birth weight preterm singleton infants with hypoxemic respiratory failure treated with milrinone and inhaled nitric oxide (iNO) compared to iNO alone: A nationwide retrospective study

Inhaled nitric oxide (iNO) has a beneficial effect on hypoxemic respiratory failure. The increased use of concurrent iNO and milrinone was observed. We aimed to report the trends of iNO use in the past 15 years in Taiwan and compare the first-year outcomes of combining iNO and milrinone to the iNO a...

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Veröffentlicht in:PloS one 2024-05, Vol.19 (5), p.e0297137-e0297137
Hauptverfasser: Chang, Ya-Ting, Liu, Jia-Rou, Chen, Wei-Min, Tseng, Chi-Nan, See, Lai-Chu
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Inhalation
Age
Apgar score
Biology and Life Sciences
Birth weight
Care and treatment
Clinical medicine
Cohort analysis
Combined treatment
Dosage and administration
Drug therapy, Combination
Dysplasia
Female
Gestational age
Health aspects
Humans
Hypoxia - drug therapy
Infant
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Infants
Infants (Premature)
Low birth weight
Lung diseases
Male
Maternal & child health
Mechanical ventilation
Medicine and Health Sciences
Methods
Milrinone
Milrinone - administration & dosage
Milrinone - therapeutic use
Mortality
National health insurance
Newborn babies
Nitric oxide
Nitric Oxide - administration & dosage
Nitric Oxide - therapeutic use
Patient outcomes
People and Places
Pneumonia
Premature babies
Pulmonary hypertension
Respiration, Artificial
Respiratory failure
Respiratory insufficiency
Respiratory Insufficiency - drug therapy
Respiratory Insufficiency - mortality
Retrospective Studies
Sepsis
Survival
Taiwan - epidemiology
Treatment Outcome
Ventilation
Ventilators
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Zusammenfassung:Inhaled nitric oxide (iNO) has a beneficial effect on hypoxemic respiratory failure. The increased use of concurrent iNO and milrinone was observed. We aimed to report the trends of iNO use in the past 15 years in Taiwan and compare the first-year outcomes of combining iNO and milrinone to the iNO alone in very low birth weight preterm (VLBWP) infants under mechanical ventilation. This nationwide cohort study enrolled preterm singleton infants with birth weight
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0297137