Association between circulating cell-free mitochondrial DNA and inflammation factors in noninfectious diseases: A systematic review
This study aimed to assess the correlation between the circulating cell-free mitochondria DNA and inflammation factors in noninfectious disease by meta-analysis of data from eligible studies. Through a comprehensive searching of pubmed, embase, web of science, cochrane from establishment of the data...
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| description | This study aimed to assess the correlation between the circulating cell-free mitochondria DNA and inflammation factors in noninfectious disease by meta-analysis of data from eligible studies.
Through a comprehensive searching of pubmed, embase, web of science, cochrane from establishment of the database to October 31, 2022, studies were selected that investigated the association of circulating cell free mitochondria DNA with inflammatory factors in non-infectious diseases. Studies that met the inclusion criteria and were published in English or Chinese were included. Data of each correlation coefficients were extracted from the paper and 95% confidence intervals were calculated. Sensitivity and heterogeneity tests were carried out for each data.
A total of 660 articles were retrieved and 22 were included in this meta-analysis, including 2600 patients. A fixed effects model was employed to examine ISS and IL-8, others were analyzed using random effects models. The correlation coefficient between mtDNA and ISS score was 0.37 (95%CI = [0.232;0.494]), p |
| doi_str_mv | 10.1371/journal.pone.0289338 |
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Through a comprehensive searching of pubmed, embase, web of science, cochrane from establishment of the database to October 31, 2022, studies were selected that investigated the association of circulating cell free mitochondria DNA with inflammatory factors in non-infectious diseases. Studies that met the inclusion criteria and were published in English or Chinese were included. Data of each correlation coefficients were extracted from the paper and 95% confidence intervals were calculated. Sensitivity and heterogeneity tests were carried out for each data.
A total of 660 articles were retrieved and 22 were included in this meta-analysis, including 2600 patients. A fixed effects model was employed to examine ISS and IL-8, others were analyzed using random effects models. The correlation coefficient between mtDNA and ISS score was 0.37 (95%CI = [0.232;0.494]), p<0.0001, heterogeneity I2 = 46%, p = 0.11). The correlation coefficients between mtDNA and inflammatory factors are as follows: TNFα, 0.405 [(95%CI = [0.253;0.538], p<0.0001, heterogeneity I2 = 77%, p = 0.0001]. IL-6, 0.469 [(95%CI = [0.296;0.612]), p = 0.0001, heterogeneity I2 = 93%, p<0.0001]. CRP, 0.333[(95%CI = [0.149;0.494]), p = 0.005, heterogeneity I2 = 85%, p<0.0001]. IL-8, 0.343[(95%CI = [0.233;0.524]), p = 0.001, heterogeneity I2 = 50%, p = 0.09]. PCT, 0.333 [(95%CI = [0.06;0.64]), p = 0.09,heterogeneity I2 = 64%,p = 0.06]. There were no significant publication bias for TNFα, IL-6 and CRP.
Circulating cell free mtDNA was moderate positively correlated with the expression of inflammatory factors and the degree of trauma.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0289338</identifier><identifier>PMID: 38241222</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Care and treatment ; Chronic diseases ; Circulation ; Communicable diseases ; Correlation coefficient ; Correlation coefficients ; Heterogeneity ; Infections ; Infectious diseases ; Inflammation ; Interleukin 6 ; Interleukin 8 ; Medical ethics ; Medical research ; Medicine, Experimental ; Meta-analysis ; Mitochondria ; Mitochondrial DNA ; Multiple organ failure ; Plasma ; Prevention ; Risk factors ; Surgery ; Trauma ; Tumor necrosis factor-α</subject><ispartof>PloS one, 2024-01, Vol.19 (1), p.e0289338-e0289338</ispartof><rights>Copyright: © 2024 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><rights>2024 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c586t-8ac2f0f5a0a8b06932b2bd9be25728920ba25eed5a286329980f6935976fb3883</cites><orcidid>0000-0003-1838-9010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0289338&type=printable$$EPDF$$P50$$Gplos$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0289338$$EHTML$$P50$$Gplos$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,2102,2928,23866,27924,27925,79472,79473</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38241222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kaewput, Wisit</contributor><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Zhang, Hao</creatorcontrib><creatorcontrib>Xu, Xin</creatorcontrib><creatorcontrib>Chen, Hairen</creatorcontrib><creatorcontrib>Qi, Baiwen</creatorcontrib><title>Association between circulating cell-free mitochondrial DNA and inflammation factors in noninfectious diseases: A systematic review</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to assess the correlation between the circulating cell-free mitochondria DNA and inflammation factors in noninfectious disease by meta-analysis of data from eligible studies.
Through a comprehensive searching of pubmed, embase, web of science, cochrane from establishment of the database to October 31, 2022, studies were selected that investigated the association of circulating cell free mitochondria DNA with inflammatory factors in non-infectious diseases. Studies that met the inclusion criteria and were published in English or Chinese were included. Data of each correlation coefficients were extracted from the paper and 95% confidence intervals were calculated. Sensitivity and heterogeneity tests were carried out for each data.
A total of 660 articles were retrieved and 22 were included in this meta-analysis, including 2600 patients. A fixed effects model was employed to examine ISS and IL-8, others were analyzed using random effects models. The correlation coefficient between mtDNA and ISS score was 0.37 (95%CI = [0.232;0.494]), p<0.0001, heterogeneity I2 = 46%, p = 0.11). The correlation coefficients between mtDNA and inflammatory factors are as follows: TNFα, 0.405 [(95%CI = [0.253;0.538], p<0.0001, heterogeneity I2 = 77%, p = 0.0001]. IL-6, 0.469 [(95%CI = [0.296;0.612]), p = 0.0001, heterogeneity I2 = 93%, p<0.0001]. CRP, 0.333[(95%CI = [0.149;0.494]), p = 0.005, heterogeneity I2 = 85%, p<0.0001]. IL-8, 0.343[(95%CI = [0.233;0.524]), p = 0.001, heterogeneity I2 = 50%, p = 0.09]. PCT, 0.333 [(95%CI = [0.06;0.64]), p = 0.09,heterogeneity I2 = 64%,p = 0.06]. There were no significant publication bias for TNFα, IL-6 and CRP.
Circulating cell free mtDNA was moderate positively correlated with the expression of inflammatory factors and the degree of trauma.</description><subject>Analysis</subject><subject>Care and treatment</subject><subject>Chronic diseases</subject><subject>Circulation</subject><subject>Communicable diseases</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Heterogeneity</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Medical ethics</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Meta-analysis</subject><subject>Mitochondria</subject><subject>Mitochondrial DNA</subject><subject>Multiple organ failure</subject><subject>Plasma</subject><subject>Prevention</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Trauma</subject><subject>Tumor 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Min</au><au>Zhang, Hao</au><au>Xu, Xin</au><au>Chen, Hairen</au><au>Qi, Baiwen</au><au>Kaewput, Wisit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between circulating cell-free mitochondrial DNA and inflammation factors in noninfectious diseases: A systematic review</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-01-19</date><risdate>2024</risdate><volume>19</volume><issue>1</issue><spage>e0289338</spage><epage>e0289338</epage><pages>e0289338-e0289338</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aimed to assess the correlation between the circulating cell-free mitochondria DNA and inflammation factors in noninfectious disease by meta-analysis of data from eligible studies.
Through a comprehensive searching of pubmed, embase, web of science, cochrane from establishment of the database to October 31, 2022, studies were selected that investigated the association of circulating cell free mitochondria DNA with inflammatory factors in non-infectious diseases. Studies that met the inclusion criteria and were published in English or Chinese were included. Data of each correlation coefficients were extracted from the paper and 95% confidence intervals were calculated. Sensitivity and heterogeneity tests were carried out for each data.
A total of 660 articles were retrieved and 22 were included in this meta-analysis, including 2600 patients. A fixed effects model was employed to examine ISS and IL-8, others were analyzed using random effects models. The correlation coefficient between mtDNA and ISS score was 0.37 (95%CI = [0.232;0.494]), p<0.0001, heterogeneity I2 = 46%, p = 0.11). The correlation coefficients between mtDNA and inflammatory factors are as follows: TNFα, 0.405 [(95%CI = [0.253;0.538], p<0.0001, heterogeneity I2 = 77%, p = 0.0001]. IL-6, 0.469 [(95%CI = [0.296;0.612]), p = 0.0001, heterogeneity I2 = 93%, p<0.0001]. CRP, 0.333[(95%CI = [0.149;0.494]), p = 0.005, heterogeneity I2 = 85%, p<0.0001]. IL-8, 0.343[(95%CI = [0.233;0.524]), p = 0.001, heterogeneity I2 = 50%, p = 0.09]. PCT, 0.333 [(95%CI = [0.06;0.64]), p = 0.09,heterogeneity I2 = 64%,p = 0.06]. There were no significant publication bias for TNFα, IL-6 and CRP.
Circulating cell free mtDNA was moderate positively correlated with the expression of inflammatory factors and the degree of trauma.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38241222</pmid><doi>10.1371/journal.pone.0289338</doi><tpages>e0289338</tpages><orcidid>https://orcid.org/0000-0003-1838-9010</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Care and treatment Chronic diseases Circulation Communicable diseases Correlation coefficient Correlation coefficients Heterogeneity Infections Infectious diseases Inflammation Interleukin 6 Interleukin 8 Medical ethics Medical research Medicine, Experimental Meta-analysis Mitochondria Mitochondrial DNA Multiple organ failure Plasma Prevention Risk factors Surgery Trauma Tumor necrosis factor-α |
| title | Association between circulating cell-free mitochondrial DNA and inflammation factors in noninfectious diseases: A systematic review |
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