Association between circulating cell-free mitochondrial DNA and inflammation factors in noninfectious diseases: A systematic review

This study aimed to assess the correlation between the circulating cell-free mitochondria DNA and inflammation factors in noninfectious disease by meta-analysis of data from eligible studies. Through a comprehensive searching of pubmed, embase, web of science, cochrane from establishment of the data...

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Veröffentlicht in:PloS one 2024-01, Vol.19 (1), p.e0289338-e0289338
Hauptverfasser: Zhou, Min, Zhang, Hao, Xu, Xin, Chen, Hairen, Qi, Baiwen
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Sprache:eng
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Zusammenfassung:This study aimed to assess the correlation between the circulating cell-free mitochondria DNA and inflammation factors in noninfectious disease by meta-analysis of data from eligible studies. Through a comprehensive searching of pubmed, embase, web of science, cochrane from establishment of the database to October 31, 2022, studies were selected that investigated the association of circulating cell free mitochondria DNA with inflammatory factors in non-infectious diseases. Studies that met the inclusion criteria and were published in English or Chinese were included. Data of each correlation coefficients were extracted from the paper and 95% confidence intervals were calculated. Sensitivity and heterogeneity tests were carried out for each data. A total of 660 articles were retrieved and 22 were included in this meta-analysis, including 2600 patients. A fixed effects model was employed to examine ISS and IL-8, others were analyzed using random effects models. The correlation coefficient between mtDNA and ISS score was 0.37 (95%CI = [0.232;0.494]), p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0289338