Evolutionary analyses of intrinsically disordered regions reveal widespread signals of conservation

Intrinsically disordered regions (IDRs) are segments of proteins without stable three-dimensional structures. As this flexibility allows them to interact with diverse binding partners, IDRs play key roles in cell signaling and gene expression. Despite the prevalence and importance of IDRs in eukaryo...

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Veröffentlicht in:PLoS computational biology 2024-04, Vol.20 (4), p.e1012028-e1012028
Hauptverfasser: Singleton, Marc D, Eisen, Michael B
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Sprache:eng
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