The tau hypothesis of nodding syndrome in Africa

[...]many individuals with NS are seropositive for ov16, indicating exposure to Onchocera volvulus (OV). [...]the tau hypothesis is open to a combination of risk factors causing NS and does not postulate an initial cause of the disease. [...]the tau hypothesis makes no statement about the cause of NS; the tau hypothesis only makes a claim about pathogenesis. [...]the key difference is that the OV hypothesis suggests that tau is a seizure-related epiphenomenon, whereas the tau hypothesis suggests a key role for tau in pathogenesis. The main gap in the tau hypothesis is that tau pathology is not etiologically specific. [...]the presence of tau pathology